Document Type

Article

Publication Date

3-2018

Department

Mathematics, Statistics, and Computer Science

Keywords

epidemiology, prospective cohort study, eicosapentaenoic acid, docosahexaenoic acid, omega-3 fatty acids

Abstract

Background: The extent to which omega-3 fatty acid status is related to risk for death from any cause and for incident cardiovascular disease (CVD) remains controversial. Objective: To examine these associations in the Framingham Heart Study. Design: Prospective and observational. Setting: Framingham Heart Study Offspring cohort. Measurements: The exposure marker was red blood cell levels of eicosapentaenoic and docosahexaenoic acids (the Omega-3 Index) measured at baseline. Outcomes included mortality (total, CVD, cancer, and other) and total CVD events in participants free of CVD at baseline. Follow-up was for a median of 7.3 years. Cox proportional hazards models were adjusted for 18 variables (demographic, clinical status, therapeutic, and CVD risk factors). Results: Among the 2500 participants (mean age 66 years, 54% women), there were 350 deaths (58 from CVD, 146 from cancer, 128 from other known causes, and 18 from unknown causes). There were 245 CVD events. In multivariable-adjusted analyses, a higher Omega-3 Index was associated with significantly lower risks (P-values for trends across quintiles) for total mortality (P = .02), for non-CVD and non-cancer mortality (P = .009), and for total CVD events (P = .008). Those in the highest (>6.8%) compared to those in the lowest Omega-3 Index quintiles (

Comments

Full-text available at publisher's site:

https://www.lipidjournal.com/article/S1933-2874(18)30061-8/fulltext

Source Publication Title

Journal of Clinical Lipidology

Publisher

Elsevier

Volume

12

Issue

3

First Page

718

DOI

10.1016/j.jacl.2018.02.010

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