invadopodia, tumor cells, stromal cells, cancer
Invadopodia are actin-rich structures at the base of many neoplastic cells that sequester matrix metalloproteases that act to degrade the surrounding stroma to facilitate the invasive process. Conventional invadopodia are dependent upon Src kinase and the large GTPase dynamin 2 (Dyn 2). Whether invadopodia are the only mechanism by which cells degrade matrix is unclear. We have observed that cells of mesenchymal origin degrade matrix in an unique way different from tumor cells. The HYPOTHESIS of this study is that fibroblasts, and other cells of mesenchymal origin, degrade matrix by a mechanism distinct from that of epithelial-based tumor cells. The CONCLUSION is that stromal cells degrade matrix by a novel mechanism distinct from traditional invadopodia.
Cao, Hong; Eppinga, Robbin; Krueger, Eugene W.; Chen, Jing; and McNiven, Mark A., "Large Scale Matrix Degradation by Stromal Cells Independent of Invadopodia" (2012). Faculty Work Comprehensive List. 187.