Document Type

Conference Presentation

Publication Date

12-18-2012

Department

Biology

Keywords

invadopodia, tumor cells, stromal cells, cancer

Abstract

Invadopodia are actin-rich structures at the base of many neoplastic cells that sequester matrix metalloproteases that act to degrade the surrounding stroma to facilitate the invasive process. Conventional invadopodia are dependent upon Src kinase and the large GTPase dynamin 2 (Dyn 2). Whether invadopodia are the only mechanism by which cells degrade matrix is unclear. We have observed that cells of mesenchymal origin degrade matrix in an unique way different from tumor cells. The HYPOTHESIS of this study is that fibroblasts, and other cells of mesenchymal origin, degrade matrix by a mechanism distinct from that of epithelial-based tumor cells. The CONCLUSION is that stromal cells degrade matrix by a novel mechanism distinct from traditional invadopodia.

Comments

Poster presented at the American Society for Cell Biology Annual Meeting in San Francisco, California, December 15-19, 2012.

Abstract #2075

Download

Share

COinS